PARK7 Mouse Monoclonal Antibody [Clone ID: AT1E12]

CAT#: AM50077PU-S

PARK7 mouse monoclonal antibody, clone AT1E12, Purified

Product Images

The cell lysates of HeLa (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PARK7 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Product Data

• Clone Name: AT1E12
• Applications: ELISA, FC, IF, WB
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Immunocytochemistry/Immunofluorescence .
  Western blot / Immunoblot.
  The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant human Park7/DJ-1 (1-189aa) purified from E. coli
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein-A affinity chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Parkinsonism associated deglycase
• Database Link:
  Entrez Gene 11315 Human
  UniProt ID Q99497
• Background: Parkinson disease (autosomal recessive, early onset) 7, also known as PARK7/DJ-1, has been shown to interact with EFCAB6 and protein inhibitor of activated STAT2. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7. This protein belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death.
• Synonyms: Oncogene DJ1, Parkinson disease protein 7

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Parkinson's disease