GCLM Mouse Monoclonal Antibody [Clone ID: AT2D12]

CAT#: AM50016PU-S

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GCLM mouse monoclonal antibody, clone AT2D12, Purified


 Product Datasheet for 'AM50016PU-S'

  View other "AT2D12" antibodies (1)

USD 220.00


Availability*
2 Weeks

Size
    • 50 ul


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Specifications

Product Data
Clone Name AT2D12
Applications ELISA, FC, IF, WB
Recommend Dilution ELISA.
Western blot: 1/3000 (using HeLa cells (40 µg), resolved by SDS-PAGE).
Flow cytometry: 2-5 µg in 1x106 cells (in HeLa cell line).
Immunofluorescence/Immnunocytochemistry: 1/100 (in HeLa cell line).
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human GCLM (1-274aa) purified from E. coli
Formulation PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
State: Purified
State: Liquid purified Ig fraction
Concentration 1.0 mg/ml
Purification Protein-G affinity chromatography
Gene Name Homo sapiens glutamate-cysteine ligase modifier subunit (GCLM), transcript variant 1
Background GCLM (Glutamate-cysteine ligase, modifier subunit), also known as gamma-glutamylcysteine synthetase, is first rate limiting enzyme of glutathione synthesis. GCLM is heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. GCLM deficiency has been implicated in some forms of hemolytic anemia. Also, GCLM is a molecular target for amelioration of cisplatin restance in lung cancer.
Synonyms Gamma-ECS regulatory subunit, GCS light chain
Reference Data
Protein Families Druggable Genome
Protein Pathways Glutathione metabolism, Metabolic pathways

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