CD1 (CD1A) Mouse Monoclonal Antibody [Clone ID: O10]

CAT#: AM33361PU-T

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CD1 (CD1A) mouse monoclonal antibody, clone O10, Purified



USD 270.00


Availability*
2 Weeks

Size
    • 20 ug


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Specifications

Product Data
Clone Name O10
Applications FC, IF, IHC, IP, WB
Recommended Dilution ELISA: Use BSA free Antibody for coating. 
Flow Cytometry: 0.5-1 µg/million cells. 
Immunofluorescence: 1-2 µg/ml. 
Immunoprecipitation:
1-2 µg/500 µg protein. 
Western Blotting: 0.5-1 µg/ml. 
Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Sections: 0.5-1 µg/ml for 30 min at RT.
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Positive Control: MOLT-4 cells, Paracortex in a tonsil or a reactive lymph node.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human thymus cells.
Specificity Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor.
Cellular Localization: Cell surface.
Formulation 10mM PBS
State: Purified
State: Liquid purified IgG fraction from Bioreactor Concentrate
Stabilizer: 0.05% BSA
Preservative: 0.05% Sodium Azide
Concentration lot specific
Purification Protein A/G Chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Predicted Protein Size 49 kDa
Gene Name CD1a molecule
Background At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin.
Synonyms T6/Leu-6, hTa1
Reference Data
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