IL12A Mouse Monoclonal Antibody [Clone ID: B-S35]

CAT#: AM32424AF-N

IL12A mouse monoclonal antibody, clone B-S35, Azide Free

Specifications

Product Data

• Clone Name: B-S35
• Applications: ELISA
• Recommended Dilution: ELISA.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: EBI3 recombinant protein and IL-35/Fc recombinant protein.
  Myeloma X63/AG.8653 x Balb/c node cells.
• Specificity: Recognises both natural and recombinant protein (no cross reaction with IL-12 and IL-27).
• Formulation: PBS without carriers and preservatives
  State: Azide Free
  State: Liquid purified (0.2 μm sterile filtered) IgG fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 12A
• Database Link:
  Entrez Gene 3592 Human
  UniProt ID P29459
• Background: IL-35 or Interleukin 35 is a cytokine belonging to the IL12 family, that is produced by regulatory T cells. It is a dimeric protein composed of IL-12-alpha and IL-27-beta chains. Members of this class of cytokines are important in influencing T helper cell differentiation and supressing inflammatory response. IL-35 is known to play an essential role in immune regulation of the CD4+CD25+ regulatory T (Treg) cells, from which IL-35 is also specifically produced. IL-35 is able to expand CD4+CD25+ Treg cells whereas it can inhibit proliferation of CD4+CD25- effector T (Teff) cells and development of proinflammatory Th17 cells, suppressing inflammatory responses.
• Synonyms: IL-12A, IL-12 subunit p35, NKSF1, CLMF p35