ACTH (POMC) Mouse Monoclonal Antibody [Clone ID: 57]

CAT#: AM32066PU-N

ACTH (POMC) mouse monoclonal antibody, clone 57, Purified

Specifications

Product Data

• Clone Name: 57
• Applications: ELISA, IHC
• Recommended Dilution: ELISA.
  Immunohistochemistry on Formalin Fixed Paraffin Sections: 1/100-1/200.
  Protein digestion pretreatment of paraffin sections e.g. trypsin or pronase is required.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Keyhole Limpet Haemocyanin conjugated Human ACTH (1-17)
• Specificity: Specific for Synacthen (1-24 ACTH).
  Reacts with ACTH (a.a. 1-17) and does not cross-react with CLIP (ACTH 17-39).
  It cross-reacts with Rat N-terminal ACTH.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: proopiomelanocortin
• Database Link:
  Entrez Gene 5443 Human
  UniProt ID P01189
• Background:

  ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output.

• Synonyms: Corticotropin, Adrenocorticotropic hormone, POMC