IL8 (CXCL8) Mouse Monoclonal Antibody [Clone ID: B-K8]

CAT#: AM31352AF-N

IL8 (CXCL8) mouse monoclonal antibody, clone B-K8, Azide Free

Specifications

Product Data

• Clone Name: B-K8
• Applications: FC, FN
• Recommended Dilution: Flow Cytometry (Intra-cytoplasmic).
  Fuctional Assay: Blocks IL-8 induced chemotaxis of Human neutrophils.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human IL-8
• Specificity: Recognises both natural and recombinant IL-8.
• Formulation: PBS, Sterile-filtered through 0.22 µm and treated to remove endotoxins.
  Carrier and preservative free
  State: Azide Free
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: C-X-C motif chemokine ligand 8
• Database Link:
  Entrez Gene 3576 Human
  UniProt ID P10145
• Background: IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood.
  This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes.
  Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
• Synonyms: CXCL8, Protein 3-10C, Emoctakin, GCP1, MDNCF, MONAP, NAP1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Bladder cancer, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway