IL6 Mouse Monoclonal Antibody [Clone ID: B-E8]

CAT#: AM31351AF-N

IL6 mouse monoclonal antibody, clone B-E8, Azide Free


USD 653.00

2 Weeks*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name B-E8
Applications ELISA, FC, FN
Recommended Dilution ELISA.
Flow Cytometry
(Intra-cytoplasmic).
Fuctional Assay: Blocks IL-6 induced proliferation on B9 cells. Inhibits IL-6 binding to its receptor.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant IL-6.
Specificity Recognises both natural and recombinant Human IL-6
Formulation PBS, Sterile-filtered through 0.22 µm and treated to remove endotoxins.
Carrier and preservative free
State: Azide Free
State: Liquid purified IgG fraction
Concentration lot specific
Purification Ion Exchange Chromatography
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens interleukin 6 (IL6), transcript variant 1
Background Interleukin 6 (IL6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.
Synonyms IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.