p53(TP53) Mouse Monoclonal Antibody [Clone ID: B-P3]
Mouse Monoclonal Anti-TP53 Antibody, Azide Free
Product Datasheet for 'AM31197AF-N'
|Recommend Dilution||IHC, FC, WB, IP|
|Immunogen||Recombinant p53 protein|
|Formulation||Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free|
|Purification||Ion Exchange Chromatography|
|Predicted Protein Size||44.1KDa|
|Gene Name||tumor protein p53|
|Background||This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].|
|Protein Families||Stem cell - Pluripotency, Transcription Factors, Druggable Genome|
|Protein Pathways||MAPK signaling pathway, Cell cycle, p53 signaling pathway, Apoptosis, Wnt signaling pathway, Neurotrophin signaling pathway, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Basal cell carcinoma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.