Siglec 7 (SIGLEC7) Mouse Monoclonal Antibody [Clone ID: 6-434]

CAT#: AM26779PU-N

Siglec 7 (SIGLEC7) mouse monoclonal antibody, clone 6-434, Purified

Specifications

Product Data

• Clone Name: 6-434
• Applications: FC
• Recommended Dilution: Flow cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human dendritic cells
• Specificity: This antibody recognizes CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.
• Formulation: Phosphate buffered saline (PBS)
  State: Purified
  State: Liquid Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 7.4
• Concentration: lot specific
• Purification: Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: sialic acid binding Ig like lectin 7
• Database Link:
  Entrez Gene 27036 Human
  UniProt ID Q9Y286
• Background: CD328, also known as Siglec-7 or p75/AIRM1, is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with alpha2,6 sialyl and alpha2,8 disyalyl residues and mediates sialic acid-dependent cell-cell binding. As it contains in its intracellular part the immunoreceptor tyrosine-based inhibitory motif (ITIM), it serves as an inhibitory receptor, e.g. of NK cells.
• Synonyms: Siglec-7, QA79 membrane protein, p75, D-siglec, CDw328, AIRM1