Msr1 Rat Monoclonal Antibody [Clone ID: 2F8]

CAT#: AM26746PU-N

Msr1 rat monoclonal antibody, clone 2F8, Purified

Specifications

Product Data

• Clone Name: 2F8
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on frozen sections: 10 µg/ml (1:100).
  Does not react on routinely processed paraffin sections.
  Sugeested positive control: Mouse spleen.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Raw 264 cell line
• Specificity: This antibody recognises the murine scavenger receptor types I and II. It inhibits the uptake of acetylated low-density lipoproteins and also inhibits divalent cation independent adhesion. The molecule recognised is expressed by tissue macrophages and functions both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages binding to ligand rich tissues, e.g. atherosclerotic lesions. Monoclonal antibody 2F8 recognizes an epitope within the α-helical coiled-coil domain of SR-A in all mouse strain s tested, with the exception of C57BL/6. One amino - acid change (L168S), due to polymorphism, results in the loss of reactivity of antibody 2F8.
• Formulation: Phosphate buffered saline pH 7.4 (PBS)
  State: Purified
  State: Liquid affinity purified Ig fraction
  Preservative: 0.09 % Sodium azide
• Concentration: 1.0 mg/ml
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  
• Stability: Shelf life: one year from despatch.
• Gene Name: macrophage scavenger receptor 1
• Database Link:
  Entrez Gene 20288 Mouse
  UniProt ID P30204
• Synonyms: MSR1, SCARA1