Melatonin Related Receptor (GPR50) Mouse Monoclonal Antibody [Clone ID: 1A3]

CAT#: AM26725PU-N

Melatonin Related Receptor (GPR50) mouse monoclonal antibody, clone 1A3, Purified

Product Images

Immunohistochemistry on paraffin section: Human pituitary stained with AM26725PU-N.

• 

  Immunohistochemistry on paraffin section: Human kidney stained with AM26725PU-N.

• 

  Immunohistochemistry on paraffin section: Human kidney stained with AM26725PU-N.

Specifications

Product Data

• Clone Name: 1A3
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 5 µg/ml.
  Positive control: Human placenta.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: DNA vaccine
• Specificity: This antibody detects Human GPR50.
• Formulation: Phosphate buffered saline pH 7.2 (PBS)
  State: Purified
  State: Lyophilized affinity purified Ig fraction
  Stabilizer: 5 mg/ml bovine serum albumin (BSA)
  Preservative: 0.1% Kathon
• Purification: Protein G
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 month or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: G protein-coupled receptor 50
• Database Link:
  Entrez Gene 9248 Human
  UniProt ID Q13585
• Background: GPR50 or me latonin - related receptor is a 617 amino acid protein that belongs to the G - protein coupled receptor 1 family, containing one disulfide bond. GPR50 does not bind melatonin and its end ogenous ligand is still unknown. Nevertheless, this receptor has been shown to behave as an antagonist of the melatonin receptor MT 1. GPR50 has been identified as a genetic risk factor for bipolar disorder and major depression in women, and it has been linked to neurite outgrowth, lipid metabolism, stress response and energy homeostasis and torpor. Its expression seems to be limited to brain, particularly the hypothalamus and pituitary.
• Synonyms: Melatonin-related receptor, G protein-coupled receptor 50, H9