chp (N-term) Mouse Monoclonal Antibody [Clone ID: JNC1]

CAT#: AM26153PU-N

chp (N-term) mouse monoclonal antibody, clone JNC1, Purified

Specifications

Product Data

• Clone Name: JNC1
• Applications: ELISA, FN, IHC, WB
• Recommended Dilution: Immuno assays.
  Flow cytometry (1:10 as starting dilution).
  Western blot (1:100 as starting dilution).
  Immunohistology on frozen sections (1:100 as starting dilution).
  Immunohistology on paraffin sections (1:100 as starting dilution).
  Inhibition of biological activity.
  Before use in biological assays, the product must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added.
• Reactivities: Staphylococcus aureus
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody detects reacts the N-terminus of CHIPS.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.01% sodium azide
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Product should be stored at 2-8°C. Under recommended storage conditions, product is stable for one year.
• Database Link:
  UniProt ID Q6GFB3
• Background:
  The bacterial pathogen Staphylococcus aureus is insensitive to antimicrobial host defense peptides such as defensins, protegrins, platelet microbicidal proteins and bacteriocins. Staphylococci have developed various resistance mechanisms including those specific for bacteriocins and several host defense peptides. A protein belonging to the resistance mechanism of Staphylococcus aureus is known as CHIPS (Chemotaxis Inhibiting Protein of Staphylococcus aureus). CHIPS is a protein produced by Staphylococcus aureus that inhibits chemotaxis of neutrophils by blocking the Formyl Peptide Receptor (FPR) and C5a Receptor on neutrophils. CHIPS and antibodies against CHIPS can be useful for various experimental infection models of Staphylococcus aureus. Furthermore these reagents can be of help in studies on the role of FPR and C5a in inflammatory processes.