Hsp60 (HSPD1) Mouse Monoclonal Antibody [Clone ID: SJ-60]

CAT#: AM20630PU-N

Mouse Monoclonal Anti-HSPD1 Antibody, Purified


 Product Datasheet for 'AM20630PU-N'

USD 390.00


Availability*
2 Weeks

Size
    • 0.1 mg


Product images

Specifications

Product Data
Clone Name SJ-60
Applications IHC, WB
Recommend Dilution IHC, IP, WB
Reactivity Chicken, Human, Rat
Host Mouse
Clonality Monoclonal
Immunogen Recombinant human heat shock protein 60 (HSP60)
Isotype IgG1
Formulation 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative
Concentration 0,1 mg/ml (after reconstitution with PBS)
Purification Affinity chromatography
Predicted Protein Size 60.9 kDa
Gene Name heat shock protein family D (Hsp60) member 1
Background Heat shock 60KD protein (HSP60) is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNFsecretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.
Synonyms CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HuCHA60; SPG13
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways RNA degradation, Type I diabetes mellitus
Other products for "HSPD1"
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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