Hsp60 (HSPD1) Mouse Monoclonal Antibody [Clone ID: SJ-60]
Mouse Monoclonal Anti-HSPD1 Antibody, Purified
Product Datasheet for 'AM20630PU-N'
|Recommend Dilution||IHC, IP, WB|
|Reactivity||Chicken, Human, Rat|
|Immunogen||Recombinant human heat shock protein 60 (HSP60)|
|Formulation||1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative|
|Concentration||0,1 mg/ml (after reconstitution with PBS)|
|Predicted Protein Size||60.9 kDa|
|Gene Name||heat shock protein family D (Hsp60) member 1|
|Background||Heat shock 60KD protein (HSP60) is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNFsecretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.|
|Synonyms||CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HuCHA60; SPG13|
|Protein Families||Druggable Genome, Stem cell - Pluripotency|
|Protein Pathways||RNA degradation, Type I diabetes mellitus|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.