CD1 (CD1D) Mouse Monoclonal Antibody [Clone ID: 51.1]

CAT#: AM20466PU-N

CD1 (CD1D) mouse monoclonal antibody, clone 51.1, Aff - Purified

Product Images

Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Staining of normal human peripheral blood cells with 0.5 ug of Purified Mouse IgG2b isotype control (open histogram) or Purified anti-human CD1d (51.1) (colored histogram) followed by Biotin Anti-Mouse IgG and Streptavidin-PE. Cells in the lymphocyte gate were used for analysis.

Specifications

Product Data

• Clone Name: 51.1
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 20 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Human CD1d
• Specificity: The monoclonal antibody reacts with Human CD1d.
• Formulation: PBS, pH 7.2 containing < / = 0.09% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody at 2-8°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens CD1d molecule (CD1D), transcript variant 1
• Database Link:
  Entrez Gene 912 Human
  UniProt ID P15813
• Background: Human CD1d, a member of the CD1 family with similarity to the non-polymorphic MHC Class I-like molecules. CD1d is a highly conserved single transmembrane receptor of the Immunoglobulin Superfamily. CD1d can associate with beta-microglobulin another feature showing similarity to MHC class I molecules, but can also exist as a nonglycosylated protein not in association with beta microglobulin. This suggests different control mechanisms for presenting glycolipid containing molecules to CD1d reactive NKT cells. Expression of CD1d is found on B cells of the periphery, in resting monocytes and cortical thymocytes. On intestinal epithelial cells (IEC) expression is polarized. Expression can also be found at low levels intracellularly in hepatocytes. In HCV (hepatitis C virus) livers, CD1d is highly expressed compared to normal controls.
• Synonyms: R3G1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Hematopoietic cell lineage