IL23 (IL23A) Mouse Monoclonal Antibody [Clone ID: HLT2736]

CAT#: AM20386PU-N

IL23 (IL23A) mouse monoclonal antibody, clone HLT2736, Purified

Product Images

Linker-free, recombinant Human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific HLT2736 antibody. Proteins were visualized using a Goat anti-Mouse secondary conjugated to HRP and a chromogen.

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  IL-23 staining of Formalin-Fixed, Paraffin-Embedded Human Lung, vasculature

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  IL-23 staining of Formalin-Fixed, Paraffin-Embedded Human Adrenal.

Specifications

Product Data

• Clone Name: HLT2736
• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human IL23A / IL23 protein
• Specificity: Detects Human recombinant p40 and p19 with elastin linker.
• Formulation: PBS, pH 7.2, sourced in TCS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 23 subunit alpha
• Database Link:
  Entrez Gene 51561 Human
  UniProt ID Q9NPF7
• Background: The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.
• Synonyms: IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway