Adenosine Receptor A2a (ADORA2A) (full length) Mouse Monoclonal Antibody [Clone ID: 7F6-G5-A2 / 7F6]

CAT#: AM12133PU-N

Adenosine Receptor A2a (ADORA2A) (full length) mouse monoclonal antibody, clone 7F6-G5-A2 / 7F6, Purified

Product Images

ADORA2A antibody staining of Formalin-Fixed Paraffin-Embedded Human Brain, Putamen at 5 ug/ml followed by Biotin conjugated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen.

Specifications

Product Data

• Clone Name: 7F6-G5-A2 / 7F6
• Applications: FC, IHC, WB
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  IHC-Pfa: 1 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Canine, Guinea Pig, Human, Mouse, Rabbit, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: 6His-tagged full-length Human recombinant A2A receptor.
  Epitope: 3rd Intracellular Domain (SQPLPGER)
• Specificity: This antibody recognizes Human Adenosine Receptor A2A at ~43 kDa.
  Does not recognize Adenosine Receptor A2A in knockout mice.
• Formulation: 0.01M Tris-Glycine, pH 7.4, 0.15M Sodium Chloride
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Purification: Protein G Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: adenosine A2a receptor
• Database Link:
  Entrez Gene 11540 MouseEntrez Gene 25369 RatEntrez Gene 135 Human
  UniProt ID P29274
• Background: The A2a Adenosine Receptor is a major target of caffeine. This receptor inhibits cell aggregation, induces vasodilation, and downregulates inflammation. This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
• Synonyms: ADORA2A, ADORA2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction