Lamin A (LMNA) Mouse Monoclonal Antibody [Clone ID: R27]
$440.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | R27 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | Immunofluorescence Microscopy. Immunoblotting (Western). Working Dilution: Ready-to-use for Immunofluorescence microscopy. Incubation Time: 1 h at RT. |
| Reactivity | Bovine, Fish, Human, Mouse, Rat, Xenopus, Zebrafish |
| Antibody Host | Mouse |
| Isotype | IgM |
| Clonality | Monoclonal |
| Immunogen | Nuclear pore complex-lamina fraction of Bovine liver. |
| Specificity | The monoclonal antibody decorates the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope. Mutations in lamin A have been shown to cause Hutchinson-Gilford progeria syndrome in Human and Mouse and other laminopathies (for review see Burke & Stewart, 2002). Polypeptide(s) Reacting: Lamin isotypes A and C (Mr 60-75 kD); meiotic lamin C2. Tested Reactivity on Cultured Cell Lines: RV-SMC (Rat Vascular Smooth Muscle Cells). |
| Buffer | State: Supernatant State: Hybridoma Culture Supernatant Preservative: 0.09% Sodium Azide |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | lamin A/C |
| Database Link | |
| Background | Lamin A and lamin C are alternative splicing products of the lamin A/C gene that is responsible for autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD). Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues. Lamins A and C, the products of the LMNA gene, are nuclear intermediate filament proteins and are the major structural components of the lamina network that underlies and supports the nuclear envelope. |
| Synonyms | LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.