BAFF (TNFSF13B) Mouse Monoclonal Antibody [Clone ID: T7-241]

CAT#: AM08333PU-N

BAFF (TNFSF13B) mouse monoclonal antibody, clone T7-241, Aff - Purified

Product Images

Tonsil: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: T7-241
• Applications: ELISA, FC, IHC
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human BAFF(TL7) protein
• Specificity: This antibody ecognizes CD257/BAFF.
• Formulation: PBS, pH 7.2 containing 0.09% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: tumor necrosis factor superfamily member 13b
• Database Link:
  Entrez Gene 10673 Human
  UniProt ID Q9Y275
• Background: Members of the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL1 (for TNF- and ApoL- related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NFkB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA. BAFF also signals through a third TNF receptor BAFFR/BR3. BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL, THANK was shown to activate NF-kB and c-jun N terminal kinase (JNK) and to induce apoptosis.
  The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain.
• Synonyms: TNFSF13B, BLYS, TALL1, TNFSF20, ZTNF4