Klra3 Hamster Monoclonal Antibody [Clone ID: 14B11]

CAT#: AM08064PU-N

Klra3 hamster monoclonal antibody, clone 14B11, Purified

Specifications

Product Data

• Clone Name: 14B11
• Applications: FC
• Recommended Dilution: Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1,3)
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Specificity: This antibody is specific to an epitope common to the Ly49C, Ly49F, Ly49H and Ly49I allelic/splice variants.
  The antibody stains ~ 90% of NK1.1+CD3- splenocytes, and ~ 6% of CD8+ spleen cells from C57BL/6 mice. (Ref.1) The antibody also stains 30-80% of NK1.1+CD3-splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: killer cell lectin-like receptor, subfamily A, member 3
• Database Link:
  Entrez Gene 16640 MouseEntrez Gene 16634 Mouse
  UniProt ID Q64329
• Background: Ly49C, Ly49F, Ly49H and Ly49I are members of the lectin like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down regulated. (Ref.2) These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells.
• Synonyms: Ly49C, Ly49F, Ly49H, Ly49I, Ly-49H, Ly-49C, Ly-49F, Ly-49I, Klra3, Klra9, Klra8, Klra6