Cd80 Rat Monoclonal Antibody [Clone ID: 1G10]
Specifications
| Product Data | |
| Clone Name | 1G10 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow Cytometry: < / = 0.2 µg/10e6 cells. (Ref.2,7) |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Specificity | This antibody recognises CD80/B7-1 (Mr. 45-47 kDa) |
| Buffer | PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: PE State: Liquid purified Ig fraction. Label: R-Phycoerythrin |
| Concentration | lot specific |
| Conjugation | PE |
| Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | CD80 antigen |
| Database Link | |
| Background | CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours postactivation. (Ref.1-4) The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. (Ref.5,6). This Monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigenpresenting cells. (Ref.2,7). |
| Synonyms | CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1 |
| Reference Data | |
| Protein Categories | CD Markers, Cytokines, Intracellular Proteins, Membrane Proteins |
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