Tfrc Rat Monoclonal Antibody [Clone ID: RI7217]
Specifications
| Product Data | |
| Clone Name | RI7217 |
|---|---|
| Application | FC, FN, IP |
| Recommended Dilution | Flow Cytometry. (Ref.1-3,5) In vivo and vitro Inhibition of Cell Proliferation. (Ref.2) Immunoprecipitation. (Ref.3) |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Specificity | This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions). RI7217 inhibits cell proliferation in vitro. (Ref.2) |
| Buffer | 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | transferrin receptor |
| Database Link | |
| Background | CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. (Ref.1,4) It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. (Ref.4) Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. |
| Synonyms | TfR1, p90, Transferrin receptor protein 1 |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Enzyme: Peptidases, Immune system diseases, Intracellular Proteins, Membrane Proteins, Secreated Proteins |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.