CD49e / ITGA5 Rat Monoclonal Antibody [Clone ID: 5H10-27]
$550.00
3 Days*
Specifications
| Product Data | |
| Clone Name | 5H10-27 |
|---|---|
| Application | FC, FN, IHC |
| Recommended Dilution | Flow Cytometry. (Ref.1) Immunohistochemistry on Frozen Sections: (Ref.7) Functional Assays: In vitro blocking of adhesion. (Ref.1,2-4,6) T-cell co-stimulation. (Ref.3) |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | C57BL/6 x A/J F1 mouse mast cell line MC/9. (Ref.1) |
| Specificity | This antibody is specific to alpha-5 subunit of the integrin alpha-5 beta-1 Fibronectin Receptor. It reacts with the alpha-5 chain (VLA-5) of the CD49e/CD29 heterodimeric Fibronectin Receptor. (Ref.1-5) Soluble 5H10-27 antibody inhibits VLA-5-mediated functions in vitro. (Ref.1,2-4,6) Immobilized 5H10-27 has also been demonstrated to co-stimulate the proliferative response of CD8+ T cells to plate-bound anti-CD3 monoclonal antibody. (Ref.3) |
| Buffer | PBS containing no preservatives. State: Low Endotoxin State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | integrin alpha 5 (fibronectin receptor alpha) |
| Database Link | |
| Background | Integrin alpha 5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell surface mediated signalling. It is expressed on thymocytes, activated T cells, mast cells, and a variety of mouse cell lines. |
| Synonyms | Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, VLA5, FNRA |
| Reference Data | |
| Protein Categories | CD Markers, Growth Factors, Membrane Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.