Cd22 Rat Monoclonal Antibody [Clone ID: 2D6]
Specifications
| Product Data | |
| Clone Name | 2D6 |
|---|---|
| Application | FC, FN, IP |
| Recommended Dilution | Flow Cytometry (Ref.2). Functional Assay: Blocking of B cell homotypic adhesion (Ref.2). Immunoprecipitation: (Ref.2) |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Specificity | This antibody is specific to CD22 (Mr 150 kDa), a B Lymphocyte Adhesion Molecule. |
| Buffer | 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | CD22 antigen |
| Database Link | |
| Background | CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. (Ref.1,2) CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion (Ref.2-4). Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation (Ref.6-9). |
| Synonyms | SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM |
| Reference Data | |
| Protein Categories | ADC Targets, CAR-T Targets, CD Markers, Intracellular Proteins, Membrane Proteins |
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