Fibrillin 1 (FBN1) Mouse Monoclonal Antibody [Clone ID: 11C1.3]
$765.00
3 Days*
Specifications
| Product Data | |
| Clone Name | 11C1.3 |
|---|---|
| Application | EM, IF, IHC, WB |
| Recommended Dilution | Immunohistochemistry: 1/50-1/100 (30-60 min at RT). (See Ref.2) Immunofluorescence. (See Ref.2) Western Blotting: < / = 1 µg/ml. Electron microscopic Immunolocalization. |
| Reactivity | Bovine, Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Microfibrils from zonular apparatus of bovine eye. |
| Specificity | This antibody recognises Fibrillin (Mr 350 kDa). |
| Buffer | PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Conjugation | Biotin |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | fibrillin 1 |
| Database Link | |
| Background | The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear.(Ref.1) In Immunohistochemical staining of paraformaldehyde-fixed human skin, mAb 11C1.3 labels the elastic framework and more specifically the oxytalantic network close to the epidermis. The antibody also exhibits discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues.(Ref.2,3) There is an aberrant expression of fibrillin in Marfan syndrome.(Ref.4) |
| Synonyms | FBN1, FBN |
| Reference Data | |
| Protein Categories | Growth Factors, Secreated Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.