CTCF Mouse Monoclonal Antibody [Clone ID: 1D11]

SKU AM06561SU-N

CTCF mouse monoclonal antibody, clone 1D11, Ascites

Product Data

• Clone Name: 1D11
• Application: ELISA, WB
• Recommended Dilution: ELISA: 1/10000.; Western Blot: 1/500 - 1/2000.
• Reactivity: Human, Monkey
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human CTCF expressed in E. Coli.
• Specificity: Recognizes CTCF
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. ; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 83 kDa
• Gene Name: CCCTC-binding factor
• Database Link:
  P49711
• Background: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.
• Synonyms: CCCTC-binding factor, CTCFL paralog

Reference Data