WDR5 Mouse Monoclonal Antibody [Clone ID: 7B11]

CAT#: AM06480SU-N

WDR5 mouse monoclonal antibody, clone 7B11, Ascites

Product Images

Western blot analysis using WDR5 mouse mAb AM06480SU-N against Hela (1) cell lysate.

Specifications

Product Data

• Clone Name: 7B11
• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human WDR5 expressed in E. Coli.
• Specificity: Recognizes WDR5 / BIG3
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 36.6 kDa
• Gene Name: WD repeat domain 5
• Database Link:
  Entrez Gene 11091 Human
  UniProt ID P61964
• Background: WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
• Synonyms: BIG-3