FGR Mouse Monoclonal Antibody [Clone ID: 6G2]

CAT#: AM06312SU-N

FGR mouse monoclonal antibody, clone 6G2, Ascites

Product Images

Western blot analysis using FGR antibody Cat.-No AM06312SU-N against HL60 (Lane 1) Raw264.7 (Lane 2) cell lysate.

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  Immunohistochemical analysis of paraffin-embedded human Spleen tissues using FGR antibody Cat.-No AM06312SU-N

Specifications

Product Data

• Clone Name: 6G2
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human FGR expressed in E. Coli.
• Specificity: Recognizes FGR (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog).
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: FGR proto-oncogene, Src family tyrosine kinase
• Database Link:
  Entrez Gene 2268 Human
  UniProt ID P09769
• Background: FGR: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as SRC2; c-fgr; c-src2; FLJ43153; MGC75096; p55c-fgr; p58c-fgr. It is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Synonyms: C-FGR, P55-FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog