CD45 (PTPRC) Mouse Monoclonal Antibody [Clone ID: 4A8A4C7A2]

CAT#: AM06301SU-N

Reviews ()
Write a review

CD45 (PTPRC) mouse monoclonal antibody, clone 4A8A4C7A2, Ascites



USD 395.00


Availability*
2 Weeks

Size
    • 100 ul


Product images

Specifications

Product Data
Clone Name 4A8A4C7A2
Applications IHC, WB
Recommended Dilution ELISA: 1/10000.
Western blot: 1/500-1/2000.
Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified recombinant fragment of CD45 expressed in E. Coli.
Specificity Recognizes CD45
Formulation State: Ascites
State: Ascitic fluid containing 0.03% Sodium Azide.
Storage Store at 4℃, for long term storage, store at -20℃.
Background CD45, also known as TPRC (protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Synonyms PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
Clone ID reveals the Source of Monoclonal Antibodies