MCK10 (DDR1) Mouse Monoclonal Antibody [Clone ID: 2G4E12]
$510.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | 2G4E12 |
|---|---|
| Application | WB |
| Recommended Dilution | ELISA: 1/10000. Western Blot: 1/500-1/2000. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified Recombinant fragment of DDR1 (aa 602-681) expressed in E. coli |
| Specificity | Recognizes Human Discoidin domain receptor tyrosine kinase 1 (DDR1). |
| Buffer | State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | discoidin domain receptor tyrosine kinase 1 |
| Database Link | |
| Background | Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. |
| Synonyms | Tyrosine kinase DDR-1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, MCK10, Epithelial discoidin domain receptor 1 |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Enzyme: Kinases, Intracellular Proteins, Membrane Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.