Lysosomal acid lipase (LIPA) Mouse Monoclonal Antibody [Clone ID: 9G7F12]

CAT#: AM06118PU-N

Lysosomal acid lipase (LIPA) mouse monoclonal antibody, clone 9G7F12, Purified

Product Images

Western blot analysis using LAL mouse mAb against LAL recombinant protein.

Specifications

Product Data

• Clone Name: 9G7F12
• Applications: ELISA, WB
• Recommended Dilution: Western Blot: 1/500 - 1/2000.
  ELISA: 1/10000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of LAL expressed in E. Coli.
• Specificity: This antibody reacts to LAL.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0,03% sodium azide
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: lipase A, lysosomal acid type
• Database Link:
  Entrez Gene 3988 Human
  UniProt ID P38571
• Background: Lysosomal acid lipase (LAL), with 378-amino acid protein( 43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.
• Synonyms: LIPA, Lysosomal acid lipase/cholesteryl ester hydrolase, LAL, Acid cholesteryl ester hydrolase, EC=3.1.1.13, Sterol esterase, Lipase A, Cholesteryl esterase