SIGLEC1 Mouse Monoclonal Antibody [Clone ID: 3B1/11]
Specifications
| Product Data | |
| Clone Name | 3B1/11 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow cytometry: Use 10 µl of Neat antibody to label 1x106 cells in 100 µl. |
| Reactivity | Porcine |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Porcine alveolar macrophages. |
| Specificity | This antibody is specific for the CD169 cell surface antigen, also known as sialoadhesin, which is expressed by subsets of cells of the macrophage/monocyte cell lineage. CD169 is preferentially expressed on cells in the late stages of maturation. It is expressed strongly on alveolar and tissue macrophages, but weakly on blood monocytes. |
| Buffer | PBS Label: FITC State: Liquid purified IgG fraction from Tissue Culture Supernatant Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide Label: Fluorescein Isothiocyanate Isomer 1 |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein G |
| Conjugation | FITC |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Database Link | |
| Background | Two families of mammalian lectin like adhesion molecules have been shown to bind glycoconjugate ligands in a sialic acid dependent manner: the selectins and the sialoadhesins. The sialoadhesin family has 4 members: CD22, a B cell specific marker; myelin associated glycoprotein (MAG), which is expressed on oligodendrocytes and Schwann cells; CD33, a myeloid differentiation antigen; and sialoadhesin, which is expressed only by a subpopulation of tissue macrophages. Involved in cell-cell interactions, sialoadhesin is structurally related to the 3 other listed members of the sialoadhesin family. CD169 is a sialic acid binding site of sialoadhesin. CD169 is a macrophage receptor expressed on stromal macrophages in many tissues, particularly found in lymph nodes, bone marrow and spleen. |
| Synonyms | Sialoadhesin, Siglec-1 |
| Reference Data | |
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