ACTH (POMC) (1-24) Mouse Monoclonal Antibody [Clone ID: 57 (BGN/1388/66)]

CAT#: AM05431PU-N

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ACTH (POMC) (1-24) mouse monoclonal antibody, clone 57 (BGN/1388/66), Aff - Purified



USD 831.00


Availability*
5 Days

Size
    • 1 mg


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Specifications

Product Data
Clone Name 57 (BGN/1388/66)
Applications ELISA, IHC
Recommended Dilution ELISA.
Immunohistochemistry on Formalin Fixed Paraffin Embedded Sections: 1/100-1/200 (Requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase).
Reactivity Human, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Synthetic peptide corresponding to the amino acids 1-24 of the Human ACTH conjugated to Keyhole Limpet Haemocyanin.
Specificity This ACTH antibody (Clone 57, BGN/1388/66) recognises 1-24 ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation.
It does not recognise 17-39 ACTH (CLIP).
Formulation PBS, pH 7.2
State: Aff - Purified
State: Liquid purified IgG fraction
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output.
Synonyms Corticotropin, Adrenocorticotropic hormone, POMC
Reference Data
Other products for "POMC"
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