Nitrotyrosine Mouse Monoclonal Antibody [Clone ID: 2A12]
$775.00
5 Days*
Specifications
| Product Data | |
| Clone Name | 2A12 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | Western Blot: 1/1000. Immunohistochemistry on Frozen Sections. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | 3-Nitrotyrosine-KLH |
| Specificity | This antibody detects 3-Nitrotyrosine. |
| Buffer | 20 mM Sodium Phosphate, 150 mM Sodium Chloride, 50% Glycerol, 3mM Sodium Azide, pH 7.5 State: Purified State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | The antibody can be shipped at 2-8°C. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Background | Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxidesignaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A (SP-A) to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis.55 kD 160 kD. |
| Synonyms | NO-Tyrosine, Nitro-Tyrosine |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.