Caspase-7 (CASP7) Mouse Monoclonal Antibody [Clone ID: MCH3-5]
$775.00
5 Days*
Specifications
| Product Data | |
| Clone Name | MCH3-5 |
|---|---|
| Application | WB |
| Recommended Dilution | Western Blot: Detects proenzyme form of human Caspase-7. Positive Control: MCF-7 cell line. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human caspase-7 protein and mouse myeloma cells. |
| Specificity | Reacts with Cysteine-requiring Aspartate Protease-7. |
| Buffer | PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid (sterile filtered) purified IgG fraction. |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: One year from despatch. |
| Shipping | Blue Ice |
| Gene Name | caspase 7 |
| Database Link | |
| Background | Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 is a 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in three varient forms. Granzyme B activates pro-caspase-7 to a form which can cleave poly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivo caspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7 has been shown to exist as dimers or high order oligomers. Caspase-7 may be an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic T-lymophocyte-induced cell killing in vivo. |
| Synonyms | CASP-7, CASP7, MCH3, CMH-1 |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.