Caspase 8 (CASP8) Mouse Monoclonal Antibody [Clone ID: FLICE 3]
$775.00
5 Days*
Specifications
| Product Data | |
| Clone Name | FLICE 3 |
|---|---|
| Application | WB |
| Recommended Dilution | Western Blot. Positive Control: MCF-7 cell lysates. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human capase-8 protein and mouse myeloma cells. |
| Specificity | This antibody detects proenzyme form of human Caspase-8 by Western blot analysis as well as one of the cleavage products. |
| Buffer | PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid (sterile filtered) purified IgG fraction |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: One year from despatch. |
| Shipping | Blue Ice |
| Gene Name | caspase 8 |
| Database Link | |
| Background | Caspases are key effectors of programmed cell death. They are synthesized as inactive proenzymes which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker which may be involved in the regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosis pathway. Caspase-8 contains two N-terminal region death effector domains which are removed to activate the enzyme along with cleavage into the two subunits. These subunits then for the active protease which is capable of cleaving caspase-3, -6 and -7. These caspases are then capable of cleaving other cellular substrates such as PARP and DFF, which in turn induce apoptosis. |
| Synonyms | CASP-8, CASP8, MCH5, CAP4 |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.