PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization.
Synonyms
Regulatory subunit 14A, Regulatory (inhibitor) subunit 14A CPI 17, Regulatory (inhibitor) subunit 14A, Protein phosphatase 1 regulatory subunit 14A, Protein phosphatase 1 regulatory (inhibitor) subunit 14A, Protein phosphatase 1, PPP1R14A, PPP1INL, PKC potentiated inhibitory protein of PP1, CPI-17, CPI 17 alpha
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