Nitrotyrosine Mouse Monoclonal Antibody [Clone ID: 39B6]
$765.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | 39B6 |
|---|---|
| Application | ELISA, IHC, IP, WB |
| Recommended Dilution | ELISA (1,6). Immunoprecipitation. Immunofluorescence. Western blot (1): 0.7 µg/ml was sufficient for detection of 5 µg SN-1 treated BSA using Goat anti-Mouse IgG-HRP as the secondary antibody. Immunohistochemistry on Frozen Sections (1,5). |
| Reactivity | Canine, Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | 3-(4-Hydroxy-3-Nitrophenyl Acetamido) Propionic Acid-BSA conjugate |
| Specificity | Recognizes 3-Nitrotyrosine moieties. No detectable cross-reactivity with non-Nitrated Tyrosine. Not species specific. |
| Buffer | PBS containing 0.09% Sodium Azide as preservative in 50% Glycerol. State: Purified State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein G. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Background | Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an mportant component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, sinophilperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high orrelation to disease states such as atherosclerosis, Alzheimer' disease, Parkinson’s disease and amyotrophic lateral sclerosis (4). |
| Synonyms | NO-Tyrosine, Nitro-Tyrosine |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.