HLAG (HLA-G) Mouse Monoclonal Antibody [Clone ID: G233]
$430.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | G233 |
|---|---|
| Application | ELISA, FC, IHC, IP |
| Recommended Dilution | Flow Cytometry: Extracellular and intracellular staining; recommended dilution: 1-4 μg/ml. Immunoprecipitation. ELISA. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Murine L cells transfected with both human beta2-microglobulin and HLA-G |
| Specificity | The antibody G233 recognizes several isoforms of HLA-G expressed in all populations of extravillous trophoblast (cell columns, interstitial trophoblast, endovascular trophoblast, placental bed giant cells). HLA-G belongs to the nonclassical MHC Class I molecules (MHC Class Ib). The antibody G233 has been found not to cross-react with any other MHC Class I antigens (HLA-A, -B, -C, -E, -F). |
| Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction |
| Concentration | lot specific |
| Purification | Protein A affinity chromatography (> 95% by SDS-PAGE) |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | major histocompatibility complex, class I, G |
| Database Link | |
| Background | HLA G belongs to the HLA class I heavy chain paralogues. It is a heterodimer consisting of a heavy chain (with a1, a2, a3 domains) and a light chain (beta 2 microglobulin). Alternate splicing provides both soluble and membrane bound forms of HLA G, with two soluble isoforms and four membrane bound isoforms. HLA G may be part of the fetal protection system and is expressed on fetal derived placental cells. |
| Synonyms | HLA-6.0, HLAG, MHC class I antigen G |
| Reference Data | |
| Atlas Protein Categories | Allergies and autoimmune diseases, Cytokines, Membrane Proteins, Secreated Proteins |
| Protein Families | Transmembrane |
| Protein Pathways | Allograft rejection, Antigen processing and presentation, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Endocytosis, Graft-versus-host disease, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Viral myocarditis |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.