CD147 (BSG) Mouse Monoclonal Antibody [Clone ID: MEM-M6/2]

CAT#: AM03093PU-N

CD147 (BSG) mouse monoclonal antibody, clone MEM-M6/2, Aff - Purified

Specifications

Product Data

• Clone Name: MEM-M6/2
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry (4 μg/ml).
  Immunohistochemistry on Paraffin Sections (10 µg/ml).
  Positive Control:Testis tissue.
• Reactivities: Human, Porcine
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: A soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the entire extracellular region of CD147 fused to the DNA coding for the hinge region, CH2 and CH3 domain of Human IgG1.
• Specificity: The antibody MEM-M6/2 recognizes extracellular Ig domain D1 of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes.
  The antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.
• Formulation: PBS, pH~7.4
  State: Aff - Purified
  State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE)
  Preservative: 15 mM Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: basigin (Ok blood group)
• Database Link:
  Entrez Gene 682 Human
  UniProt ID P35613
• Background: CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function.
• Synonyms: Basigin, BSG, EMMPRIN, TCSF