PRKACA Mouse Monoclonal Antibody [Clone ID: 6D2.1]

CAT#: AM03041PU-N

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PRKACA mouse monoclonal antibody, clone 6D2.1, Aff - Purified

 Product Datasheet for 'AM03041PU-N'

USD 230.00

2 Weeks

    • 100 ug

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Product Data
Clone Name 6D2.1
Applications WB
Recommend Dilution Suitable for Western Blotting (0.5-1 μg/ml).
Positive control: HeLa human cervix carcinoma cell line
Note: To detect PKAc gamma, use a more concentrated lysate from a tissue expressing this subunit (testis).
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Peptide corresponding to amino acids ESPAQNTAHLDQFERIK of human proteinkinase A c alpha (PKAc alpha).
Specificity This antibody strongly reacts with human proteinkinase A catalytic (PKAc) alpha subunit, and weakly with PKAc gamma subunit (both around 40 kDa).
The recognized epitope of PKAc alpha is identical between man, sheep, pig, ox and dog.
Formulation PBS, pH 7.4 with 15 mM sodium azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Protein A affinity chromatography.
Background Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior. PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers. The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors. However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.
Synonyms PKA C-alpha
Reference Data
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