DcR2 (TNFRSF10D) Mouse Monoclonal Antibody [Clone ID: TRAIL-R4-01]
$615.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | TRAIL-R4-01 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow Cytometry: 3 µg/ml. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | TRAIL-R4 (aa 1-210) - hIgGhc fusion protein |
| Specificity | The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells. |
| Buffer | PBS containing 15 mM Sdium Azide as preservative and 0.2% (w/v) high-grade (Protease free) BSA as a stabilizing agent. Label: PE State: Liquid purified IgG fraction. Label: R-Phycoerythrin under optimum conditions |
| Concentration | lot specific |
| Purification | Size-Exclusion Chromatography. |
| Conjugation | PE |
| Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid prolonged exposure to light. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | tumor necrosis factor receptor superfamily member 10d |
| Database Link | |
| Background | TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4). |
| Synonyms | TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4 |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity |
Reviews
Documents
| Product Manuals |
| FAQs |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.