CD24 Mouse Monoclonal Antibody [Clone ID: SN3]
CAT#: AM03032PU-N
CD24 mouse monoclonal antibody, clone SN3, Purified
Other products for "CD24"
Specifications
Product Data | |
Clone Name | SN3 |
Applications | FC, IHC |
Recommended Dilution | Flow Cytometry. Immunohistochemistry (frozen sections). Positive tissue: tonsil. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Glycoproteins purified from human NALM-1 cell line |
Specificity | The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes. |
Formulation | PBS, pH 7.4 with 15 mM sodium azide as preservative State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) |
Concentration | lot specific |
Purification | Protein A affinity chromatography |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | CD24 molecule |
Database Link | |
Background | CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid. |
Synonyms | X62 heat stable antigen, HSA |
Reference Data |
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