CD24 Mouse Monoclonal Antibody [Clone ID: SN3]
Specifications
| Product Data | |
| Clone Name | SN3 |
|---|---|
| Application | FC, IHC |
| Recommended Dilution | Flow Cytometry. Immunohistochemistry (frozen sections). Positive tissue: tonsil. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Glycoproteins purified from human NALM-1 cell line |
| Specificity | The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes. |
| Buffer | PBS, pH 7.4 with 15 mM sodium azide as preservative State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) |
| Concentration | lot specific |
| Purification | Protein A affinity chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | CD24 molecule |
| Database Link | |
| Background | CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid. |
| Synonyms | X62 heat stable antigen, HSA |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Chemokines, Cytokines, Growth Factors, Intracellular Proteins |
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