Heparan-Sulfate-Proteoglycan Mouse Monoclonal Antibody [Clone ID: 2H7/G11]
$195.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | 2H7/G11 |
|---|---|
| Application | ELISA, IHC, WB |
| Recommended Dilution | ELISA (less than 1 µg/ml). Western blot (1 µg/ml). Immunohistochemistry (1 µg/ml) |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified Human small basement membrane Heparan Sulfate Proteoglycan (HS-PG) |
| Specificity | This Monoclonal antibody is specific for a core protein epitope of a Human small basement membrane Heparan Sulfate proteo-glycan (HS-PG). AM02103PU recognizes an epitope different from that recognized by clones 1F10/B8 (Cat.-No AM02102PU) and 2E2/B5 (Cat.-No AM20231PU). |
| Buffer | PBS, pH 7.4, 20 mM D-(+)-trehalose dihydrate, 40 mM D-(-)-mannitol State: Lyophilized purified IgG fraction |
| Reconstitution Method | Restore in aqua bidest to 1 mg/ml. |
| Purification | Protein G Chromatography |
| Conjugation | Unconjugated |
| Storage | Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: One year from despatch. |
| Shipping | Ambient |
| Background | The principal molecular structure of basement membranes has been elucidated during the past two decades and it was shown that for example in the glomerular basement membrane (GBM) HS-PG are responsible for the selective filtration process. Removal of HS-PG will lead to proteinuria. Whereas previously perlecan was the only known basement membrane HS-PG, there is now evidence that (at least two) other basement membrane HS-PG do exist: Agrin, originally discovered as an important component of the neuromuscular junction and a novel small HS-PG, that was isolated from human aorta and kidney. This HS-PG, with a molecular weight of 80-200 kDa (aorta) and 30-160 kDa (kidney) and a core protein size of 24 kDa or 22 kDa, respectively, was localized by immunohistoche-mistry to the basement membrane. Amino acid sequence ana-lysis of tryptic peptides indicate, that this small HS-PG is clearly distinct from perlecan and agrin. |
| Synonyms | small Heparan sulfate proteoglycan core protein |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.