Complement factor B (CFB) (Ba Fragment) Mouse Monoclonal Antibody [Clone ID: 014III-33.2.4.3]
SKU
AM01348PU-N
Complement factor B (CFB) (Ba Fragment) mouse monoclonal antibody, clone 014III-33.2.4.3, Purified
$845.00
5 Days*
Specifications
| Product Data | |
| Clone Name | 014III-33.2.4.3 |
|---|---|
| Application | ELISA, FC, FN, IHC, WB |
| Recommended Dilution | Western Blot. Functional Assays. Flow Cytometry. ELISA: This antibody binds both the Ba fragment and the whole protein so is not suitable for all ELISA applications. Immunohistochemistry on frozen sections. Recommended Positiv Control: Kidney from post streptoccal glomerulonephritis patients. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified human complement factor b. |
| Specificity | This antibody recognises the 30kDa Ba fragment of 90kDa complement factor B, present in blood serum. |
| Buffer | Borate buffered saline pH 8.2 - 8.4 containing 0.02% Sodium Azide State: Purified State: Liquid purified Ig |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein A |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | complement factor B |
| Database Link | |
| Background | C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes. |
| Synonyms | Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD |
| Note | This antibody inhibits the function of factor B and binds both nascent factor B and the Ba cleavage product. Removal of Sodium Azide is recommended prior to use in functional assays. |
| Reference Data | |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
| Protein Pathways | Complement and coagulation cascades |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.