Factor I (CFI) Mouse Monoclonal Antibody [Clone ID: 3R/8]
$1,055.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | 3R/8 |
|---|---|
| Application | ELISA, FN, IHC, WB |
| Recommended Dilution | ELISA: 1/3000 - 1/4000. Western Blot. Functional Assays. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Native human factor I from serum. |
| Specificity | This antibody recognises complement factor I, a member of the peptidase S1 family present in the blood plasma. |
| Buffer | Borate buffered saline pH 8.4 containing 0.02% Sodium Azide State: Purified State: Liquid purified Ig |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein A |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | complement factor I |
| Database Link | |
| Background | Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors. Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome. |
| Synonyms | CFI, IF, KAF, AHUS3, C3BINA, C3b-INA |
| Note | This antibody blocks function of complement factor I. Removal of Sodium Azide is recommended prior to use in functional assays. |
| Reference Data | |
| Atlas Protein Categories | Cardiovascular diseases, Enzyme: Peptidases, Immune system diseases, Nervous system Diseases, Secreated Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.