Factor H (CFH) Mouse Monoclonal Antibody [Clone ID: 10-10]
$845.00
5 Days*
Specifications
| Product Data | |
| Clone Name | 10-10 |
|---|---|
| Application | ELISA, FC, IHC, WB |
| Recommended Dilution | ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified human factor H from serum. |
| Specificity | This antibody recognises Complement Factor H which exists in 2 forms. |
| Buffer | Borate buffered saline pH 8.4 containing 0.02% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein A. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | complement factor H |
| Database Link | |
| Background | Complement factor H exists in 2 forms, the most common form, of 150kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy. |
| Synonyms | CFH, HF, HF1, HF2, H factor 1 |
| Reference Data | |
| Atlas Protein Categories | Allergies and autoimmune diseases, Cardiovascular diseases, Intracellular Proteins, Nervous system Diseases, Secreated Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.