Clusterin (CLU) Mouse Monoclonal Antibody [Clone ID: 3R3/2]
$890.00
5 Days*
Specifications
| Product Data | |
| Clone Name | 3R3/2 |
|---|---|
| Application | ELISA, FC, IHC, WB |
| Recommended Dilution | ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptocial glomerulonephritis patients. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Glomerular basement membrane from a post-mortem kidney. |
| Specificity | This antibody recognises clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. |
| Buffer | Borate buffered saline pH 8.4 containing 0.02% Sodium Azide State: Purified State: Liquid purified Ig |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein A |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | clusterin |
| Database Link | |
| Background | Clusterin exists in two forms; a pro-apoptotic form localised to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimers disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells. |
| Synonyms | Clusterin, APOJ, CLI, KUB1, AAG4, NA1/NA2, SP-40,40 |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.