Complement C4A (C4A) Mouse Monoclonal Antibody [Clone ID: 10-12]
$775.00
5 Days*
Specifications
| Product Data | |
| Clone Name | 10-12 |
|---|---|
| Application | ELISA, FC, IHC, WB |
| Recommended Dilution | Western Blot. Flow Cytometry. ELISA: This antibody binds both C4c and C4 and so is not suitable for all ELISA applications. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Recommended Postive Control: Kidney sections from post-streptococal glomerulonephritis pastients. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified Human Complement C4c. |
| Specificity | This antibody recognises complement component 4c (C4c). |
| Buffer | Borate buffered saline, pH 8.4 State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein A |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | complement component 4A (Rodgers blood group) |
| Database Link | |
| Background | The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4bs alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma. |
| Synonyms | Complement Component 4, CPAMD2, CPAMD3 |
| Reference Data | |
| Protein Pathways | Complement and coagulation cascades, Systemic lupus erythematosus |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.