Epstein Barr Virus / EBV LMP2A Rat Monoclonal Antibody [Clone ID: 15F9]
$675.00
5 Days*
Specifications
| Product Data | |
| Clone Name | 15F9 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | Western Blot: 1/100-1/1000. Immunohistochemistry on Paraffin Sections: This product requires antigen retrieval using heat treatment methods prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose. |
| Reactivity | Epstein Barr Virus |
| Antibody Host | Rat |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Bacterial TrpE-LMP2A fusion protein. |
| Specificity | This antibody recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV) and does not cross react with LMP2B. |
| Buffer | PBS, pH 7.4 containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein G |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Background | EBV is a human herpesvirus, which is associated with conditions such as Hodgkins disease and Burkitts Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. |
| Synonyms | HHV4, HHV-4 |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.